Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use.
other · Level V
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- Record sourced from PubMed, PMID 30239814.
- Also identified by DOI 10.1093/infdis/jiy551 and PMC identifier 6350947.
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Abstract
Rising azithromycin nonsusceptibility among Neisseria gonorrhoeae isolates threatens current treatment recommendations, but the cause of this rise is not well understood. We performed an ecological study of seasonal patterns in macrolide use and azithromycin resistance in N. gonorrhoeae, finding that population-wide macrolide use is associated with increased azithromycin nonsusceptibility. These results, indicative of bystander selection, have implications for antibiotic prescribing guidelines.
Medical subject headings
- Anti-Bacterial Agents
- Azithromycin
- Drug Resistance, Bacterial
- Drug Utilization
- Gonorrhea
- Macrolides
- Neisseria gonorrhoeae