Chromatin Domains Go on Repeat in Disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30241613.
- Also identified by DOI 10.1016/j.cell.2018.08.068.
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Abstract
TAD boundaries are insulators of genomic neighborhoods. In this issue, Sun et al. show that disease-associated tandem repeats are located to TAD boundaries and affect their insulation. The findings have important implications for TAD function and mechanisms underlying diseases such as fragile X syndrome and Huntington's disease.
Medical subject headings
- Chromatin
- Fragile X Syndrome