A novel role for Tamm-Horsfall protein (uromodulin) in the renal tubule.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 30243308.
- Also identified by DOI 10.1016/j.kint.2018.06.023.
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Abstract
Tamm-Horsfall protein (THP)/uromodulin, the most abundant urinary protein, is produced in the thick ascending limb of the loop of Henle. Besides immunological functions, it has regulatory impact on ion transport and volume regulation. It had been debated whether the distal convoluted tubule is a source for THP as well. Novel results suggest that in its early portions, THP synthesis affects adaptive plasticity of the epithelium, stabilizes calcium homeostasis, and activates the thiazide-sensitive Na<sup>+</sup>,Cl<sup>-</sup>-cotransporter.
Medical subject headings
- Kidney Tubules, Distal
- Uromodulin