Impact of cellular phosphate handling on vascular calcification.
Level V
Where this comes from
- Record sourced from PubMed, PMID 30243309.
- Also identified by DOI 10.1016/j.kint.2018.06.027.
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Abstract
Cardiovascular calcification is still a major burden for patients with chronic kidney disease (CKD). The pathomechanism of vascular calcification is complex, involving numerous processes. In this issue, Yamada et al. describe a protective role of Pit-2 within this context by using PiT-2 heterozygous mice with CKD fed a high-phosphate diet. The mechanisms still need to be elucidated. Pit-2 could become a potential therapeutic target.
Medical subject headings
- Renal Insufficiency, Chronic
- Vascular Calcification