Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30244974.
- Also identified by DOI 10.1016/j.cmet.2018.09.007 and PMC identifier 6542592.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
PAHSAs are anti-diabetic and anti-inflammatory lipids. Syed et al. identify numerous experimental differences that likely account for the failure of Pflimlin et al. to observe PAHSA beneficial effects. The differences include different HFDs resulting in minimal/no glucose intolerance, different assay conditions, an LC-MS protocol that was not validated, and use of olive oil, a bioactive nutrient that improves glucose tolerance, as a vehicle.
Medical subject headings
- Blood Glucose
- Lipids