Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 30258056.
- Also identified by DOI 10.1038/s41467-018-06234-w and PMC identifier 6158214.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρ<sub>genetic</sub> = -0.59, p-value = 3.14 × 10<sup>-6</sup>), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology.
Medical subject headings
- Genome, Human
- Lateral Ventricles