Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30262473.
- Also identified by DOI 10.1126/science.aas9824 and PMC identifier 7350422.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Chen <i>et al</i> (Reports, 17 February 2017, p. 752) highlight an important problem of sequencing artifacts caused by DNA damage at the time of sample processing. However, their manuscript contains several errors that led the authors to incorrect conclusions. Moreover, the same sequencing artifacts were previously described and mitigated in The Cancer Genome Atlas and other published sequencing projects.
Medical subject headings
- Artifacts
- DNA Damage