Lanthanide phosphate (LnPO₄ ) rods as bio-probes: A systematic investigation on structural, optical, magnetic, and biological characteristics.

Abstract

The proposed work involves an exclusive study on the synthesis protocol, crystal structure analysis, and imaging contrast features of unique lanthanide phosphates (LnPO₄ ). XRD and Raman spectra affirmed the ability of the proposed synthesis technique to achieve unique LnPO₄ devoid of impurities. The crystal structure analysis confirms the P121/c1 space setting of NdPO₄ , EuPO₄ , GdPO₄ , and TbPO₄ that all uniformly crystallizes in monoclinic unit cell. In a similar manner, the tetragonal crystal setting of DyPO₄ , ErPO₄ , HoPO₄ , and YbPO₄ that unvaryingly possess the I41/amd space setting is confirmed. Under the same synthesis conditions, the monoclinic (Eu) and tetragonal (Ho) lanthanide phosphates displayed uniform rod-like morphologies. Absorption and luminescence properties of unique LnPO₄ were determined. In vitro biological studies demonstrated low toxicity levels of LnPO₄ and clearly distinguished fluorescence of TbPO₄ and EuPO₄ in Y79, retinoblastoma cell lines. The paramagnetic response of GdPO₄ , NdPO₄ , DyPO₄ , TbPO₄ , and HoPO₄ facilitated excellent magnetic resonance imaging (MRI) contrast features. Meanwhile, GdPO₄ , DyPO₄ , HoPO₄ , and YbPO₄ possessing higher X-ray absorption coefficient than clinical contrast Omnipaque™ exhibited high computed tomography (CT) efficiency. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1372-1383, 2019.