Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 30275568.
- Also identified by DOI 10.1038/s41591-018-0201-9 and PMC identifier 6511988.
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Abstract
We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19<sup>-</sup> leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufacturing, and its product bound in cis to the CD19 epitope on the surface of leukemic cells, masking it from recognition by and conferring resistance to CTL019.
Medical subject headings
- Antigens, CD19
- Drug Resistance, Neoplasm
- Epitopes
- Leukemia