RAIDD mutations underlie the pathogenesis of thin lissencephaly (TLIS).
basic_science · Level V
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- Record sourced from PubMed, PMID 30281648.
- Also identified by DOI 10.1371/journal.pone.0205042 and PMC identifier 6169973.
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Abstract
Abnormal regulation of caspase-2-mediated neuronal cell death causes neurodegenerative diseases and defective brain development. PIDDosome is caspase-2 activating complex composed of PIDD, RAIDD, and caspase-2. Recent whole-exome sequencing study showed that the RAIDD mutations in the death domain (DD), including G128R, F164C, R170C, and R170H mutations, cause thin lissencephaly (TLIS) by reducing caspase-2-mediated neuronal apoptosis. Given that the molecular structure of the RAIDD DD:PIDD DD complex is available, in this study, we analyzed the molecular mechanisms underlying TLIS caused by the RAIDD TLIS variants by performing mutagenesis and biochemical assays.
Medical subject headings
- CRADD Signaling Adaptor Protein
- Lissencephaly