Distinct Hypothalamic and Brainstem Contributions to Lorcaserin Action.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30282043.
- Also identified by DOI 10.1016/j.cmet.2018.09.016.
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Abstract
Pro-opiomelanocortin (POMC)-expressing neurons regulate energy balance and mediate the effects of some classes of anti-obesity therapeutics. In this issue of Cell Metabolism, D'Agostino et al. (2018) demonstrate that a small and often overlooked population of POMC neurons in the brainstem contributes to satiation induced by the FDA-approved drug lorcaserin.
Medical subject headings
- Receptor, Serotonin, 5-HT2C
- Serotonin