AMPK Regulates the Epigenome through Phosphorylation of TET2.
Level V
Where this comes from
- Record sourced from PubMed, PMID 30282044.
- Also identified by DOI 10.1016/j.cmet.2018.09.015.
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Abstract
Emerging evidence suggests that changes to cellular metabolism can regulate epigenetic modifications to alter gene expression. Recently in Nature, Wu et al. show that the metabolic regulator AMPK can phosphorylate and thus stabilize the epigenetic modifying enzyme TET2, defining a novel signaling link between metabolism and the epigenome.
Medical subject headings
- Diabetes Mellitus
- Neoplasms