Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30282046.
- Also identified by DOI 10.1016/j.cmet.2018.09.018.
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Abstract
Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. (2018) and Raud et al. (2018) now report that LC-FAO is largely dispensable for these processes.
Medical subject headings
- Fatty Acids
- Macrophages