Laser trapping/confocal Raman spectroscopic characterization of PLGA-PEG nanoparticles.
basic_science · Level V
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- Record sourced from PubMed, PMID 30283943.
- Also identified by DOI 10.1039/c8sm01364k.
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Abstract
We have immobilized poly(ethylene glycol) (PEG) on the surfaces of poly(lactic-co-glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e., SOCl2 halogenate-alcoholysis and DCC dehydration. The immobilized PLGA nanoparticles were characterized by DLS, 1H NMR, FT-IR and laser trapping/confocal Raman spectroscopic techniques. As a result, especially the Raman spectra which were measured after optically trapping ca. 10 individual nanoparticles in solution indicated that the PLGA nanoparticles were successfully immobilized with the PEG by the chemical methods.