Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30284958.
- Also identified by DOI 10.1089/ten.TEA.2018.0226 and PMC identifier 6590728.
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Abstract
This study compared side-by-side the impact of donor age on the production of tissue-engineered small intestine (TESI). Each age represents a specific period of life: E18 for fetuses, 5-day-old pups for neonates, 21-day-old rats for weanlings, and 6-week-old rats for adults. The TESI produced was compared macroscopically and microscopically. The mechanism(s) contributing to the differences observed was explored by detecting proliferating cells in the TESI and by analyzing intestinal stem cell gene expression in donor cells. These data may provide valuable information for future application of TESI clinically.
Medical subject headings
- Aging
- Intestine, Small
- Organoids
- Stem Cells
- Tissue Engineering
- Tissue Scaffolds