The Cellular and Molecular Basis for Planarian Regeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30290140.
- Also identified by DOI 10.1016/j.cell.2018.09.021 and PMC identifier 7706840.
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Abstract
Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over 2 centuries. Recent findings identify key cellular and molecular principles underlying these feats. A stem cell population (neoblasts) generates new cells and is comprised of pluripotent stem cells (cNeoblasts) and fate-specified cells (specialized neoblasts). Positional information is constitutively active and harbored primarily in muscle, where it acts to guide stem cell-mediated tissue turnover and regeneration. I describe here a model in which positional information and stem cells combine to enable regeneration.
Medical subject headings
- Planarians
- Regeneration