Lost in Translation: Deciphering the Mechanism of Action of Anti-human CTLA-4.
review · Level V
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- Record sourced from PubMed, PMID 30291135.
- Also identified by DOI 10.1158/1078-0432.CCR-18-2509.
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Abstract
Despite a number of preclinical studies demonstrating that the activity of anti-CTLA-4 antibodies in murine models of cancer relies on effector T-cell activation and regulatory T cell depletion, the activity of the clinical antibodies remains controversial. To decipher such mechanisms is critical to the development of novel and more potent immunotherapies.See related article by Sharma et al., p. 1233.
Medical subject headings
- Neoplasms
- T-Lymphocytes, Regulatory