Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30291230.
- Also identified by DOI 10.1038/s41467-018-06534-1 and PMC identifier 6173770.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time directly from nanoliter amounts of blood and other bodily fluids. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous, and non-invasive sensors for metabolites for point-of-care and home diagnostics.
Medical subject headings
- Asparagine
- Biosensing Techniques
- Glucose
- Nanopores