Role of <sup>18</sup>F-fluoro-ethyl-tyrosine Positron Emission Tomography in Investigation and Management of Suspected Gliomas.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 30300714.
- Also identified by DOI 10.1016/j.wneu.2018.09.194.
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Abstract
This study aims to investigate the utility of <sup>18</sup>F-fluoro-ethyl-tyrosine (<sup>18</sup>F-FET) positron emission tomography in surgical decision making in suspected glioma. A retrospective review of patients undergoing <sup>18</sup>F-FET positron emission tomography was performed. Previously published thresholds for maximum tumor background ratios (TBRs) were used for quantitative analysis. Forty-seven patients were included in the study, of whom 15 had confirmed glioma and 7 had a confirmed alternative diagnosis. <sup>18</sup>F-FET showed significantly higher uptake in high-grade glioma than in nonglioma. Lesions with TBR<sub>max</sub> >2.5 should be considered suspicious for glioma and biopsy considered. Threshold TBR<sub>max</sub> >3.0 is useful for differentiating high-grade glioma from low-grade glioma. This may be a particularly useful tool for directing management in eloquent areas, such as brainstem glioma.
Medical subject headings
- Brain Neoplasms
- Disease Management
- Glioma
- Positron-Emission Tomography