The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma.
case_report · Level V
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- Record sourced from PubMed, PMID 30303917.
- Also identified by DOI 10.1097/AOG.0000000000002920.
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Abstract
The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses. A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium. The sign of Leser-Trelát can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy.
Medical subject headings
- Acanthosis Nigricans
- Adenocarcinoma
- Endometrial Neoplasms
- Fallopian Tube Neoplasms
- Keratosis, Seborrheic
- Neoplasms, Cystic, Mucinous, and Serous
- Neoplasms, Multiple Primary
- Paraneoplastic Syndromes