Direct Diagnostic Tests for Lyme Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30307486.
- Also identified by DOI 10.1093/cid/ciy614 and PMC identifier 6399434.
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Abstract
Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. These serologic tests cannot distinguish active infection, past infection, or reinfection. Reliable direct-detection methods for active B. burgdorferi infection have been lacking in the past but are needed and appear achievable. New approaches have effectively been applied to other emerging infections and show promise in direct detection of B. burgdorferi infections.
Medical subject headings
- Borrelia burgdorferi
- Lyme Disease