Stem Cells, Genome Editing, and the Path to Translational Medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30340033.
- Also identified by DOI 10.1016/j.cell.2018.09.010 and PMC identifier 6461399.
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Abstract
The derivation of human embryonic stem cells (hESCs) and the stunning discovery that somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) holds the promise to revolutionize biomedical research and regenerative medicine. In this Review, we focus on disorders of the central nervous system and explore how advances in human pluripotent stem cells (hPSCs) coincide with evolutions in genome engineering and genomic technologies to provide realistic opportunities to tackle some of the most devastating complex disorders.
Medical subject headings
- Central Nervous System Diseases
- Gene Editing
- Stem Cell Transplantation
- Translational Research, Biomedical