Flipping ATP to AMPlify Kinase Functions.
editorial · Level V
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- Record sourced from PubMed, PMID 30340038.
- Also identified by DOI 10.1016/j.cell.2018.10.011 and PMC identifier 6421561.
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Abstract
Understanding protein kinase family members that lack key catalytic residues-or pseudokinases-is a major challenge in cell signaling. In this issue of Cell, Sreelatha et al. (2018) describe how one pseudokinase transfers adenosine monophosphate (AMP) rather than phosphate to protein substrates, revealing unexpected catalytic diversity for the kinase fold.
Medical subject headings
- Protein Kinases
- Signal Transduction