Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30341591.
- Also identified by DOI 10.1007/s00223-018-0484-3.
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Abstract
Nephronectin (Npnt), an extracellular matrix protein, is known to be a ligand of integrin α8β1, and it has also been known to play critical roles as various organs. In the present study, elevated extracellular inorganic phosphate (Pi) strongly inhibited the expression of Npnt in MC3T3-E1 cells, while the existence of extracellular calcium (Ca) was indispensable for its effect. Furthermore, Pi-induced inhibition of Npnt gene expression was recovered by inhibitors of both sodium-dependent Pi transporter (Pit) and fibroblast growth factor receptors (Fgfrs). These results demonstrated that Npnt gene expression is regulated by extracellular Pi via Pit and Fgfrs.
Medical subject headings
- Extracellular Matrix Proteins
- Osteoblasts
- Phosphates