Hypoxia and TGF-β3 Synergistically Mediate Inner Meniscus-Like Matrix Formation by Fibrochondrocytes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30343640.
- Also identified by DOI 10.1089/ten.TEA.2018.0211.
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Abstract
The interactions of hypoxia and TGF-β3 in aggregates of human meniscus fibrochondrocytes are synergistic in nature, suggesting combinatorial strategies using these factors are promising for tissue engineering the inner meniscus regions. Hypoxia alone in the absence of TGF-β supplementation may be insufficient to initiate an inner meniscus-like extracellular matrix-forming response in this model.
Medical subject headings
- Chondrocytes
- Extracellular Matrix
- Fibroblasts
- Meniscus
- Transforming Growth Factor beta3