The discovery and importance of genomic imprinting.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30343680.
- Also identified by DOI 10.7554/eLife.42368 and PMC identifier 6197852.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The discovery of genomic imprinting by Davor Solter, Azim Surani and co-workers in the mid-1980s has provided a foundation for the study of epigenetic inheritance and the epigenetic control of gene activity and repression, especially during development. It also has shed light on a range of diseases, including both rare genetic disorders and common diseases. This article is being published to celebrate Solter and Surani receiving a 2018 Canada Gairdner International Award "for the discovery of mammalian genomic imprinting that causes parent-of-origin specific gene expression and its consequences for development and disease".
Medical subject headings
- DNA Methylation
- Epigenesis, Genetic
- Genomic Imprinting