Real-Time Imaging of Free Radicals for Mitochondria-Targeting Hypoxic Tumor Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30350653.
- Also identified by DOI 10.1021/acs.nanolett.8b02670.
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Abstract
Free radicals have emerged as new-type and promising candidates for hypoxic tumor treatment, and further study of their therapeutic mechanism by real-time imaging is of great importance to explore their biomedical applications. Herein, we present a smart free-radical generator AuNC-V057-TPP for hypoxic tumor therapy; the AuNC-V057-TPP not only exhibits good therapeutic effect under both hypoxic and normoxic conditions but also can monitor the release of free radicals in real-time both in vitro and in vivo. What is more, with the mitochondria-targeting ability, the AuNC-V057-TPP is demonstrated with improved antitumor efficacy through enhanced free radical level in mitochondria, which leads to mitochondrial membrane damage and ATP production reduction and finally induces cancer cell apoptosis.
Medical subject headings
- Drug Delivery Systems
- Free Radicals
- Gold
- Mammary Neoplasms, Animal
- Metal Nanoparticles
- Mitochondria
- Molecular Imaging
- Tumor Hypoxia