Bone Marrow-Derived Macrophages Enhance Vessel Stability in Modular Engineered Tissues.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30351235.
- Also identified by DOI 10.1089/ten.TEA.2018.0222.
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Abstract
This work demonstrates an effective method of enhancing the stability of a newly formed vasculature in modular engineered tissues <i>in vivo</i> through the counterintuitive implantation of allogeneic macrophages. Furthermore, we provide a detailed method for analyzing macrophage phenotype in vascularized explants and assess the role of added mesenchymal stromal cells (MSC) on that phenotype. Enhanced vascular stability may permit the development of increasingly large, clinically relevant tissues, fully permeated by blood vessels integrated with the host vasculature.
Medical subject headings
- Adipose Tissue
- Bone Marrow Cells
- Human Umbilical Vein Endothelial Cells
- Macrophages
- Mesenchymal Stem Cells
- Neovascularization, Physiologic
- Tissue Engineering