Endovascular Thrombectomy.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 30355186.
- Also identified by DOI 10.1161/STROKEAHA.118.022919.
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Abstract
Background and Purpose- This study aimed to explore safety of tirofiban in endovascular treatment of acute ischemic stroke. Methods- Two hundred eighteen ischemic stroke patients receiving endovascular thrombectomy were prospectively recruited, with 94 treated with intra-arterial tirofiban and 124 were not. The 2 groups were compared in terms of symptomatic intracranial hemorrhage (ICH) and fatal ICH rate by the χ<sup>2</sup> test and logistic regression. Results- Patients treated with tirofiban compared with those without tirofiban had significantly higher rate of symptomatic ICH (14.6% versus 5.7%; P=0.027) and fatal ICH (8.8% versus 1.6%; P=0.014). Tirofiban-treated patients had increased odds of symptomatic ICH by 2.9-fold (95% CI, 1.1-7.5), and odds of fatal ICH increased by 5.9-fold (95% CI, 1.2-28.4). Conclusions- Tirofiban treatment increases risk of major ICH after endovascular thrombectomy for acute ischemic stroke in this nonrandomized study.
Medical subject headings
- Endovascular Procedures
- Fibrinolytic Agents
- Intracranial Hemorrhages
- Postoperative Hemorrhage
- Stroke
- Thrombectomy
- Tirofiban