Angiotensin II- and Alzheimer-Type Cardiovascular Aging.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 30355238.
- Also identified by DOI 10.1161/CIRCRESAHA.118.313477 and PMC identifier 6205200.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Over the past millennium, great strides have been made in expanding the human life span. Such gains however, have come with the cost of increasing age-related diseases such as Alzheimer’s disease. Slowing “biological” aging therefore may be a way to reduce morbidity and significantly impact the quality of life for the elderly. Enhanced angiotensin II (Ang II) signal transduction has been implicated in premature aging and evidence exists for the prolongation of life through blockade of the Ang II type-1 receptor (AT<sub>1</sub>R). In this Viewpoint article, we will discuss noteworthy similarities between Ang II pathophysiology and Alzheimer’s disease as potential intervention points to promote healthy aging.
Medical subject headings
- Aging
- Alzheimer Disease
- Angiotensin II
- Brain
- Cardiovascular Diseases
- Cardiovascular System
- Renin-Angiotensin System