Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30356046.
- Also identified by DOI 10.1038/s41467-018-06869-9 and PMC identifier 6200803.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views on ENM-induced bio-effects. Here we report a multi-hierarchical nano-SAR assessment for a representative ENM, Fe<sub>2</sub>O<sub>3</sub>, by metabolomics and proteomics analyses. The established nano-SAR profile allows the visualizing of the contributions of seven basic properties of Fe<sub>2</sub>O<sub>3</sub> to its diverse bio-effects. For instance, although surface reactivity is responsible for Fe<sub>2</sub>O<sub>3</sub>-induced cell migration, the inflammatory effects of Fe<sub>2</sub>O<sub>3</sub> are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). These nano-SARs are examined in THP-1 cells and animal lungs, which allow us to decipher the detailed mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1-dependent signaling. This study provides more insights for nano-SARs, and may facilitate the tailored design of ENMs to render them desired bio-effects.
Medical subject headings
- Nanostructures
- Nanotubes