Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After αβTCR-CD19-Depleted Stem Cell Transplantation.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 30357314.
- Also identified by DOI 10.1093/cid/ciy820.
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Abstract
Here, we report the case of severe adenoviremia in a 7-year-old boy with highly-resistant, acute leukemia. A combined approach of αβTCR-CD19-depleted stem cell transplantation, enabling immunosuppression-free post-transplant care, and early transfer of adenovirus-specific donor T cells during aplasia resulted in rapid and complete clearance of the treatment-refractory adenoviremia.
Medical subject headings
- Adenovirus Infections, Human
- Hematopoietic Stem Cell Transplantation
- T-Lymphocytes
- Viremia