Rotavirus Vaccine Take in Infants Is Associated With Secretor Status.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 30357332.
- Also identified by DOI 10.1093/infdis/jiy573.
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Abstract
Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P = .016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.
Medical subject headings
- Histocompatibility Antigens
- Rotavirus
- Rotavirus Infections
- Rotavirus Vaccines
- Seroconversion