Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease.
Where this comes from
- Record sourced from PubMed, PMID 30375391.
- Also identified by DOI 10.1038/s41467-018-06894-8 and PMC identifier 6207674.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression networks that regulate the workings, and failings, of the heart.
Medical subject headings
- Heart Diseases
- Myocardium
- Sequence Analysis, RNA
- Single-Cell Analysis