Anatomic and Cellular Niches for Mycobacterium tuberculosis in Latent Tuberculosis Infection.

Mayito, Jonathan; Andia, Irene; Belay, Mulugeta; Jolliffe, David A; Kateete, David P; Reece, Stephen T; Martineau, Adrian R · J Infect Dis · 2019

review · Level V

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Abstract

Latent tuberculosis has been recognized for over a century, but discovery of new niches, where Mycobacterium tuberculosis resides, continues. We evaluated literature on M.tuberculosis locations during latency, highlighting that mesenchymal and hematopoietic stem cells harbor organisms in sensitized asymptomatic individuals.

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