Improving the Enzymatic Stability and the Pharmacokinetics of Oligonucleotides via DNA-Backboned Bottlebrush Polymers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30376347.
- Also identified by DOI 10.1021/acs.nanolett.8b03662 and PMC identifier 6571500.
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Abstract
Herein, we design and synthesize site-specifically PEGylated oligonucleotide hairpins and demonstrate that their ability to undergo hybridization chain reaction is nearly unaffected by the PEGylation. The resulting DNA-backboned bottlebrush polymers with PEG side chains exhibit increased resistance against nucleolytic degradation, enhanced thermal stabilities, and elevated blood retention times in vivo, which collectively pave the way for more therapeutically focused DNA nanostructure designs.
Medical subject headings
- Oligonucleotides
- Polyethylene Glycols