Genome-wide meta-analysis identifies 3 novel loci associated with stroke.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 30383316.
- Also identified by DOI 10.1002/ana.25369 and PMC identifier 6644297.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We conducted a European-only and transancestral genome-wide association meta-analysis in 72,147 stroke patients and 823,869 controls using data from UK Biobank (UKB) and the MEGASTROKE consortium. We identified an exonic polymorphism in NOS3 (rs1799983, p.Glu298Asp; p = 2.2E-8, odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.04-1.07) and variants in an intron of COL4A1 (rs9521634; p = 3.8E-8, OR = 1.04, 95% CI = 1.03-1.06) and near DYRK1A (rs720470; p = 6.1E-9, OR = 1.05, 95% CI = 1.03-1.07) at genome-wide significance for stroke. Effect sizes of known stroke loci were highly correlated between UKB and MEGASTROKE. Using Mendelian randomization, we further show that genetic variation in the nitric oxide synthase-nitric oxide pathway in part affects stroke risk via variation in blood pressure. Ann Neurol 2018;84:934-939.
Medical subject headings
- Collagen Type IV
- Genetic Predisposition to Disease
- Nitric Oxide Synthase Type III
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Stroke