Distinct functional elements for outer-surface anti-interference and inner-wall ion gating of nanochannels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30385758.
- Also identified by DOI 10.1038/s41467-018-06873-z and PMC identifier 6212446.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Over the decades, widespread advances have been achieved on nanochannels, including nanochannel-based DNA sequencing, single-molecule detection, smart sensors, and energy transfer and storage. However, most interest has been focused on the contribution from the functional elements (FEs) at the inner wall (IW) of nanochannels, whereas little attention has been paid to the contribution from the FEs at the nanochannels' outer surface (OS). Herein, we achieve explicit partition of FE<sub>OS</sub> and FE<sub>IW</sub> based on accurate regional-modification of OS and IW. The FE<sub>IW</sub> are served for ionic gating, and the chosen FE<sub>OS</sub> (hydrophobic or charged) are served for blocking interference molecules into the nanochannels, decreasing the false signals for the ionic gating in complex environments. Furthermore, we define a composite factor, areas of a radar map, to evaluate the FE<sub>OS</sub> performance for blocking interference molecules.