Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30388415.
- Also identified by DOI 10.1016/j.stem.2018.10.012.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.
Medical subject headings
- Genomic Imprinting
- Reproduction