Stem-Cell-Derived Astrocytes Divulge Secrets of Mutant GFAP.
editorial · Level V
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- Record sourced from PubMed, PMID 30388417.
- Also identified by DOI 10.1016/j.stem.2018.10.020.
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Abstract
Gain-of-function mutations in the canonical astrocyte protein, GFAP, cause a fatal neurodevelopmental disorder with myelination abnormalities, seizures, and psychomotor disturbances. Recently, Li et al. (2018) (in Cell Stem Cell) and Jones et al. (2018) (in Cell Reports) have shown that patient iPSC-derived astrocytes with mutant GFAP have disrupted astrocyte functions, revealing disease mechanisms and potential roles of GFAP.
Medical subject headings
- Alexander Disease
- Induced Pluripotent Stem Cells
- Oligodendrocyte Precursor Cells