IGF1 Brings Growing Pains for T-ALL LSCs.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30388418.
- Also identified by DOI 10.1016/j.stem.2018.10.022.
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Abstract
Hematopoietic progenitors undergo marked shifts during transition from fetal to postnatal life, and the implication of these changes for the cell-of-origin of childhood leukemia are unclear. In this issue of Cell Stem Cell, Giambra et al. (2018) show that epigenetically regulated IGF1 signaling regulates the ability of fetal-liver- or bone-marrow-derived cells to initiate T-ALL.
Medical subject headings
- Leukemia, Myeloid, Acute
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma