The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells.
editorial · Level V
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- Record sourced from PubMed, PMID 30388419.
- Also identified by DOI 10.1016/j.stem.2018.10.003.
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Abstract
Clonal hematopoiesis of indeterminate potential (CHIP) describes clonal selection of a hematopoietic stem cell with a somatic mutation that confers increased fitness, influenced by a selective environment such as aging, inflammation, or therapeutic exposure. In this issue of Cell Stem Cell, Hsu et al. (2018) explore the role of cytotoxic therapy in disease-relevant CHIP.
Medical subject headings
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells