The Helix Twist: Damage and Repair Follows the DNA Minor Groove.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30388449.
- Also identified by DOI 10.1016/j.cell.2018.10.034.
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Abstract
Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.
Medical subject headings
- Germ-Line Mutation
- Nucleosomes