Prognostic Models Turn the Heat(IT)up on <i>FLT3<sup>ITD</sup></i> -Mutated AML.
editorial · Level V
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- Record sourced from PubMed, PMID 30389660.
- Also identified by DOI 10.1158/1078-0432.CCR-18-3146 and PMC identifier 6339517.
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Abstract
The presence of internal tandem duplications (ITD) in the <i>FLT3</i> receptor tyrosine kinase gene have long been known to confer a poor prognosis in patients with acute myeloid leukemia. Now, specific structural features of the ITDs are also suggested to alter patient outcome, including sensitivity to targeted therapies, prompting their evaluation in therapeutic algorithms.<i>See related article by Schwartz et al., p. 573</i>.
Medical subject headings
- Leukemia, Myeloid, Acute
- fms-Like Tyrosine Kinase 3