Preserving Preclinical PET Quality During Intratherapeutic Imaging in Radionuclide Therapy with Rose Metal Shielding Reducing Photon Flux.

Abstract

Performing PET imaging during ongoing radionuclide therapy can be a promising method to follow tumor response in vivo. However, the high therapeutic activity can interfere with the PET camera performance and degrade both image quality and quantitative capabilities. As a solution, low-energy photon emissions from the therapeutic radionuclide can be highly attenuated, still allowing sufficient detection of annihilation photons in coincidence. <b>Methods:</b> Hollow Rose metal cylinders with walls 2-4 mm thick were used to shield a ²²Na point source and a uniform phantom filled with ¹⁸F as they were imaged on a preclinical PET camera with increasing activities of ¹⁷⁷Lu. A mouse with a subcutaneous tumor was injected with ¹⁸F-FDG and imaged with an additional 120 MBq of ¹⁷⁷Lu and repeated with shields surrounding the animal. <b>Results:</b> The addition of ¹⁷⁷Lu to the volume imaged continuously degraded the image quality with increasing activity. The image quality was improved when shielding was introduced. The shields showed a high ability to produce stable and reproducible results for both spatial resolution and quantification of up to 120 MBq of ¹⁷⁷Lu activity (maximum activity tested). <b>Conclusion:</b> Without shielding, the activity quantification will be inaccurate for time points at which therapeutic activities are high. The suggested method shows that the shields reduce the noise induced by the ¹⁷⁷Lu and therefore enable longitudinal quantitative intratherapeutic imaging studies.