Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF.
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- Record sourced from PubMed, PMID 30389827.
- Also identified by DOI 10.1136/thoraxjnl-2018-211851 and PMC identifier 6475110.
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Abstract
Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article in <i>Thorax</i> described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange in IPF lungs. In a population of patients with IPF, we find that the xenon signal from red blood cells diminishes relative to the tissue/plasma signal over a 12-month time period, even when the diffusion factor for carbon monoxide is static over the same time period. We conclude that hyperpolarised <sup>129</sup>Xe MR spectroscopy may be sensitive to short-term changes in interstitial gas diffusion in IPF.
Medical subject headings
- Idiopathic Pulmonary Fibrosis
- Lung
- Pulmonary Diffusing Capacity
- Pulmonary Gas Exchange
- Xenon Isotopes