Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma.
basic_science · Level V
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- Record sourced from PubMed, PMID 30395349.
- Also identified by DOI 10.1002/bjs.11022.
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Abstract
Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guide the use of PBD in this patient group. The effect of PBD on hepatic gene expression profiles was therefore studied by microarray analysis. Drainage affects inflammatory and fibrotic gene signatures.
Medical subject headings
- Bile Duct Neoplasms
- Cholestasis
- Drainage
- Gene Expression
- Klatskin Tumor