When Soluble Fibers Meet Hepatocellular Carcinoma: The Dark Side of Fermentation.

Gallage, Suchira; Kotsiliti, Elena; Heikenwalder, Mathias · Cell Metab · 2018

editorial · Level V

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Abstract

Fermentation of dietary soluble fibers by our gut microbiota generates short-chain fatty acids (SCFAs) and metabolites, upholding health and being a valuable food supplement. Recently, in Cell, Singh et al. (2018) discovered that fermentable, dietary soluble fibers (e.g., inulin) induced cholestasis and hepatocellular carcinoma (HCC) while improving metabolic dysfunction.

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