Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30409859.
- Also identified by DOI 10.1126/science.aao0666 and PMC identifier 6376486.
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Abstract
Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b<sup>+</sup> perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.
Medical subject headings
- Allergens
- Anaphylaxis
- Cell-Derived Microparticles
- Dendritic Cells
- Mast Cells
- Skin