Closed-loop all-optical interrogation of neural circuits in vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30420686.
- Also identified by DOI 10.1038/s41592-018-0183-z and PMC identifier 6513754.
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Abstract
Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity 'on the fly' during behavior.
Medical subject headings
- Nerve Net
- Neurons
- Optical Imaging
- Optogenetics